Processing and Mosaicing of Fibered Confocal Images

New imaging technologies allow the acquisition of in vivo and in situ microscopic images at the cellular resolution in any part of the living body. The automated analysis of these images raises specific issues which require the development of new image processing techniques. In this work, we present some of these issues, and describe some recent advances of microscopic image processing, in particular the automatic construction of very large mosaics from times series of microscopic images to enlarge the field of view. This is also a step to bridge the gap between microscopic and higher resolution images like MRI, PET, SPECT or US. The paper is illustrated with state-of-the-art examples on small animals and humans for biological or clinical applications.